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[1] [2] The precise mechanism in humans remains incompletely understood and is based partly on extrapolation from preclinical data and from clinical observations with approved GLP-1 receptor agonists

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The GLP-1 receptor agonists used clinically are based on exendin-4 and native GLP-1 and are available as formulations for daily or weekly s.c

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These medications (most frequently levothyroxine) can sometimes trigger side effects, and missing a dose might escalate the symptoms