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Methods Animal studies All animal experiments were approved by the Institutional Animal Care and Use Committee (IACUC) of Nanjing Medical University (IACUC-2306028) (Nanjing, China)

The current recommendation from clinicians is to monitor drug levels more frequently when initiating tirzepatide in patients on immunosuppressants, and to consider separating oral medication timing from tirzepatide injection days

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Symptom improvement: Reducing diabetes symptoms, such as excessive thirst, frequent urination, and fatigue, may indicate effective medication management