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Entry Version: Citation: Pancreapedia: Exocrine Pancreas Knowledge Base , DOI: 10.3998/panc.2021.06 Abstract: Glucagon like peptide-1 (GLP-1) is a GI hormone produced in endocrine cells in the distal small intestine by alternative processing of the proglucagon gene product
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These effects are especially important with respect to treatment of hedonic overeating in obesity, a more recent indication of GLP1-R agonists [30, 31]
Pilot clinical studies and case reports describe nausea in 65% of subjects at doses above 0,5 mg (resolution 2-4 h post-injection), flushing in 55%, transient increases in blood pressure and tachycardia in 40-60% of subjects, with peak acute effects occurring 90-120 minutes post-dose
L.GondeauC.PhelipC.VarbanovM.TeissierE.et al (2013)
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