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DKD develops in ~20%40% of patients with diabetes, with incidence influenced by factors such as diabetes duration, glycemic control, and genetic susceptibility (3)

As an analog of endogenous amylin, it is studied for its receptor-mediated signaling dynamics, sustained activation profile, and downstream neuroendocrine cascades within controlled laboratory environments

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Total cholesterol (TC), Triglyceride TG, glucose, AST, ALT, creation, albumin were determined by Richomond [12], Jacobs and Vander Mark [13], Trinder [14], Larsen [15], Esen [16], Reitman and Frankel [17]